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KMID : 0608520110170010153
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Korean Journal of Oriental Medicine
2011 Volume.17 No. 1 p.153 ~ p.165
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Effect of Ligustri Lucidi Fructus Extract and Vici Herba Extract on Treatment of Osteoporosis in Ovariectomized Rat
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Lee Sang-Yun
Seo Bu-Il
Park Ji-Ha
Roh Seong-Soo
Kim Dae-Jun
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Abstract
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Objectives: The present study had been undertaken to investigate the effects of Ligustri Lucidi Fructus Extract and Vici Herba Extract on treatment of osteoporosis in ovariectomized rats.
Method: In this experiment, the rats were ovariectomized. Rats were individually administered by water extract from Ligustri Lucidi Fructus or Vici Herba(dose：1㎖/100g, 2times/day). The levels of bone mineral density, serum components, urinary components, bony components, body weight and uterus weight were measured.
Results: The levels of spinal and femoral bone mineral density(BMD) were significantly increased in comparison with OVX group at 8 weeks after administration in Vici Herba group. The levels of serum osteocalcin showed significant decrease in comparison with OVX group at 4 weeks after administration in Ligustri Lucidi Fructus and Vici Herba group. The levels of serum ALP and phosphorus showed significant decrease in comparison with OVX group at 4, 8 weeks in after administration in Ligustri Lucidi Fructus and Vici Herba group. The levels of urinary deoxypyridinoline showed significant decrease in comparison with OVX group in Ligustri Lucidi Fructus group. The levels of fibula-tibial ash weight showed significant increase in comparison with OVX group after administration in Ligustri Lucidi Fructus group. The levels of body weight were significantly decreased in comparison with OVX group at 4 weeks after administration in Ligustri Lucidi Fructus group and at 4, 8 weeks after administration in Vici Herba group. The levels of uterus weight were not significantly increased in comparison with OVX group in Ligustri Lucidi Fructus and Vici Herba group.
Conclusion: Reviewing these experimetal results, it appeared that Ligustri Lucidi Fructus and Vici Herba had efficacy on treatment of osteoporosis.
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KEYWORD
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Ligustri Lucidi Fructus, Vici Herba, treatment of osteoporosis, ovariectomized rats
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